— The Evidence

Studies Database

A structured, filterable database of peer-reviewed psilocybin studies — design, sample size, findings, and limitations for each, with links to the primary sources and our plain-English breakdowns.

— The evidence, structured 13 studies

Studies Database.

Not essays — the studies themselves. Filter by condition, sort by sample size or evidence strength, and follow each entry to its primary source and our plain-English breakdown.

13 Studies indexed
6 Rated established
11 Conditions covered
842 Total participants
Study Condition Year n Evidence
Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder Bogenschutz, Ross, Bhatt, et al. · NYU Langone Alcohol use disorder 2022 95 emerging
Increased global integration in the brain after psilocybin therapy for depression Daws, Timmermann, Giribaldi, et al. · Imperial College London Depression (brain imaging) 2022 59 emerging
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression Goodwin, Aaronson, Alvarez, et al. (COMPASS Pathways) · Multi-site (COMPASS Pathways COMP360) Treatment-resistant depression 2022 233 established
Trial of psilocybin versus escitalopram for depression Carhart-Harris, Giribaldi, Watts, et al. · Imperial College London Major depressive disorder 2021 59 emerging
Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial Davis, Barrett, May, et al. · Johns Hopkins University Major depressive disorder 2021 24 emerging
Self-blinding citizen science to explore psychedelic microdosing Szigeti, Kartner, Blemings, et al. · Imperial College London Microdosing (wellbeing and cognition) 2021 191 emerging
Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels Madsen, Fisher, Burmester, et al. · University of Copenhagen Healthy volunteers (pharmacology) 2019 8 established
Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study Carhart-Harris, Bolstridge, Rucker, et al. · Imperial College London Treatment-resistant depression 2016 12 emerging
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer Griffiths, Johnson, Carducci, et al. · Johns Hopkins University Cancer-related depression and anxiety 2016 51 established
Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer Ross, Bossis, Guss, et al. · NYU Langone Cancer-related anxiety and depression 2016 29 established
Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction Johnson, Garcia-Romeu, Cosimano, Griffiths · Johns Hopkins University Tobacco addiction 2014 15 speculative
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin Carhart-Harris, Erritzoe, Williams, et al. · Imperial College London Healthy volunteers (brain imaging) 2012 30 established
Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Griffiths, Richards, McCann, Jesse · Johns Hopkins University Healthy volunteers (mystical-type experience) 2006 36 established

Each entry links to a plain-English breakdown and to the primary source. indicates an external journal link.

How to read this. Sample size and study design matter as much as the headline finding. A large, well-controlled trial outweighs a small open-label pilot. Confidence ratings reflect our assessment of the evidence strength, not the importance of the topic. Learn how to read a clinical trial →

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Every Friday we add the most important new psilocybin study to this database and send you the 90-second breakdown. Stay current without reading the journals.

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