Glossary

A subtype of serotonin receptor and the primary target of classical psychedelics including psilocin.

A coordinated set of brain regions associated with self-referential thinking and the construction of a continuous narrative self.

A research study that tests a medical intervention on human participants under structured protocols.

The microscopic filaments that branch and interconnect to form the body of a fungus.

The vegetative body of a fungus — a network of filaments that lives mostly hidden in substrate.

A reproductive cell of a fungus, analogous in function to a seed but structurally far simpler.

The ongoing process of making meaning from a psychedelic experience and incorporating insights into daily life.

A category of profound subjective experience characterized by ineffability, unity, transcendence of time, and noetic quality.

The mindset (set) and physical/social environment (setting) in which a psychedelic experience occurs.

The active metabolite of psilocybin and the compound directly responsible for psychedelic effects.

A naturally occurring psychedelic prodrug found in over 200 species of fungi.

A chemical class of compounds derived from the amino acid tryptophan.