Key finding — Psilocybin reliably occasioned mystical-type experiences, and two months later the majority of volunteers rated the session among the most personally meaningful and spiritually significant experiences of their lives.
Study at a glance
| Field | Detail |
|---|---|
| Institution | Johns Hopkins University |
| Design | Randomized, double-blind, active-controlled crossover |
| Sample size | 36 participants |
| Intervention | 30 mg/70kg psilocybin vs. methylphenidate active control |
| Year | 2006 |
| Condition | Healthy volunteers (mystical-type experience) |
| Journal | Psychopharmacology |
| Evidence | established |
Limitations
Healthy, screened, hallucinogen-naive volunteers; outcomes are subjective self-reports rather than clinical endpoints.
Editorial note
The study that reopened modern psychedelic research after decades of dormancy. Its rigorous demonstration that psilocybin reliably produces meaningful mystical-type experiences set the methodological template for the field.
Summary written by MMI Editorial for clarity. Always consult the primary source for full methodology and results. The confidence rating reflects our assessment of evidence strength.